Evaluating the Cytotoxicity of 6-Mercaptopurine and Its Derivatives on Cancer Cells (P1-P1)

Abstract

This research aims to find the cytotoxic effects of 6-Mercaptopurine (6-MP) and its derivatives, namely 6-Hydroxy-2-Mercaptopurine (6H2MP) and 2-Amino-9-butyl-6-Mercaptopurine (2A9B6-MP), on HepG2 and MCF-7 cancer cell lines. It utilizes quantitative methods to research cell viability via MTT assays at different concentrations of these compounds. The outcome showed that 6-MP has strong cytotoxicity on HepG2 cells, with MCF-7 being more resistant. Comparison studies suggested that 6-MP was more potent than its derivatives. The results have underlined the potential use of 6-MP in the treatment of liver cancer and point to a need for further research in molecular mechanisms and in vivo validations.