Investigating the Role of Gut Microbiome Metabolites in Diabetic Chronic Kidney Disease

Abstract

Gut microbiome metabolites play a very complex role in the progression of Diabetic Chronic Kidney Disease, with the necessity to understand the mechanistic pathways connecting these metabolites with kidney health. This article discusses the five critical points: the role of gut microbiota in the formation of DCKD-related metabolites, host genes being targeted, mechanistic pathways involved, microbial species and DCKD, and therapeutic potential of such an interaction. Utilizing computational models and enrichment analyses, findings confirm the significant role of specific metabolites such as 3-Indole propionic acid and microbial species like F. prausnitzii in mitigating DCKD progression. These metabolites modulate disease pathways, particularly the MAPK/NF-KB1 signaling, showcasing potential therapeutic applications. This research bridges gaps in understanding the gut-kidney axis and emphasizes the need for experimental validation to advance microbiome-targeted interventions for DCKD managemen